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Depression - Have been taking 100mg Trazodone for insomnia for several years and for the last few months it has helped me fall asleep most nhts, but I hae been waking up between 2 and 5 a.m. Depression. Serotonin. Xanax, triazolam Halcion, buspirone BuSpar and others. Your doctor will have to adjust the doses of these drugs downward if taken.