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Reglan, Metozolv ODT metoclopramide dosing, indications. 2 mg/kg IV (infused over at least 15 minutes) 30 minutes before chemotherapy, then repeated 2 more times q2hr (after initial dose) Vomiting suppressed: Decrease to 1 mg/kg IV q3hr for 3 doses Vomiting not suppressed: Continue same dose q3hr for 3 doses May cause tardive dyskinesia (often irreversible) Risk of developing tardive dyskinesia increases with treatment duration and total cumulative dose Discontinue with sns or symptoms of tardive dyskinesia No known treatment exists for tardive dyskinesia Symptoms may lessen or resolve after metoclopramide treatment is stopped Do not administer for longer than 12 weeks, except in rare cases where therapeutic benefit is thought to outweh risk of tardive dyskinesia Hypersensitivity to metoclopramide or procainamide GI hemorrhage, mechanical obstruction, perforation, history of seizures, pheochromocytoma Other drugs causing extrapyramidal symptoms (eg, phenothiazines, butyrophenones) Mental depression reported; use with caution in patients with history of mental illness Use with caution or avoid in parkinson disease patients; may have increased risk of extrapyramidal symptoms Use with caution after GI anastomosis or closure; promotility agents reported to increase pressure in suture lines Use caution in patients with hypertension, CHF, renal impairment, cirrhosis Use caution in patients who are at risk of fluid overload Can cause tardive dyskinesia (see Black Box Warnings), especially in elderly; discontinue if sns or symptoms of tardive dyskinesia develop (metoclopramide itself may completely or partially suppress these manifestations); tardive dyskinesia may persist even after drug is discontinued Diphenhydramine 50 mg IM can be given for extrapyramidal symptoms Pseudoparkisonism (eg, tremor, ridity) may occur within 6 months of therapy; reversible within 2-3 months of discontinuing therapy Metoclopramide IV administration associated with catecholamine release; use caution in patients with hypertension Hypertensive crisis reported in patients with undiagnosed pheochromocytoma; discontinue therapy immediately with any sudden increase in blood pressure during therapy May cause QT prolongation and torsades de pointes in some patients with heart failure patients that also have renal impairment; data on healthy males have failed to show similar effects; implicatiosn unclear; use caution in cardiovascular disease Pregnancy category: B; No association was observed between exposure to metoclopramide during pregnancy and an increased risk of birth defects, spontaneous abortion, or stillbirth, according to results of a large, register-based study [JAMA 2013 310(15)]; other studies have also shown no association with first trimester use and major congenital malformations [N Engl J Med 2009 360(24)] Lactation: Drug crosses into breast milk; use caution; concern may be warranted according to American Academy of Pediatrics Blocks dopamine receptors (at hh dose) and serotonin receptors in chemoreceptor trger zone of CNS; and sensitizes tissues to acetylcholine; increases upper GI motility but not secretions; increases lower esophageal sphincter tone Half-life (IV/IM): 5-6hr (adults); 4 hr (children) Dialyzable: Not snificant; dose adjustment after dialysis unnecessary Total body clearance: 0.53-0.55 L/hr/kg (prolonged in neonates as compared with adults) Excretion: Primarily urine (85%) Solution: D5W (at hh drug concentration) Additive: Dexamethasone sodium phosphate with lorazepam and diphenhydramine, erythromycin lactobionate, floxacillin, fluorouracil, furosemide Syringe: Ampicillin, calcium gluconate, coramphenicol sodium succinate, furosemide, methotrexate, penicillin G potassium, sodium bicarbonate Y-site: Allopurinol, amphotericin B cholesteryl sulfate, amsacrine, cefepime, doxorubicin liposomal, furosemide, propofol Additive: Cimetidine, clindamycin, meperidine, meropenem, morphine sulphate, potassium coride, verapamil Syringe (partial list): Butorphanol, corpromazine, cisplatin, cyclophosphamide, cytarabine, dexamethasone, dimenhydrinate, diphenhydramine, doxorubicin, fentanyl, fentanyl with midazolam, fluorouracil, heparin, hydromorphone, hydroxyzine, insulin, lidocaine, magnesium sulfate, meperidine, midazolam, morphine, ondansetron, pentazocine, procorperazine, promethazine, ranitidine, vitamins B and C Y-site (partial list): Aztreonam, bivalirudin, ciprofloxacin, cisplatin, cytarabine, diltiazem, docetaxel, doxorubicin, famotidine, fentanyl, fluconazole, fluorouracil, heparin, hydromorphone, linezolid, meperidine, morphine sulfate, ondansetron, quinupristin-dalfopristin, zidovudine The above information is provided for general informational and educational purposes only. Medscape - Gastroparesis, nausea, vomiting-specific dosing for Reglan, Metozolv ODT metoclopramide, frequency-based adverse effects, comprehensive.
Ciprofloxacin Ciprofloxacin And Alkeran Taken Together Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. Ciprofloxacin and metoclopramide taken together. overnht ciprofloxacin cod shipping. ciprofloxacin with no prescription and delivered overnht